Molecular markers as indicators of antimalarial drug failure rates
نویسندگان
چکیده
منابع مشابه
In vitro antimalarial susceptibility and molecular markers of drug resistance in Franceville, Gabon
BACKGROUND Malaria remains a major public health problem, due largely to emergence and widespread P. falciparum drug resistance. WHO recommends artemisinine combination based therapy (ACT) to overcome P. falciparum drug resistance, but reports of declining ACT efficacy have been published. A thorough understanding of the molecular bases of P. falciparum resistance to existing drugs is therefore...
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Chloroquine (CQ) and fansidar (sulphadoxine-pyrimethamine, SP) were widely used for treatment of Plasmodium falciparum for several decades in Malaysia prior to the introduction of Artemisinin-based Combination Therapy (ACT) in 2008. Our previous study in Kalabakan, located in south-east coast of Sabah showed a high prevalence of resistance to CQ and SP, suggesting the use of the treatment may n...
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ژورنال
عنوان ژورنال: Tropical Medicine & International Health
سال: 2007
ISSN: 1360-2276
DOI: 10.1111/j.1365-3156.2007.01928.x